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IonOptix myocyte calcium and contractility system
Myocyte Calcium And Contractility System, supplied by IonOptix, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/calcium+and+contractility+system/myocyte+calcium+and+contractility+system/pm40568844-339-22-18
Average 90 stars, based on 1 article reviews
myocyte calcium and contractility system - by Bioz Stars, 2026-09
90/100 stars

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Related Articles

other:

Article Title: Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis.
Article Snippet: In this case we paced the cells at 1Hz and obtained the calcium handling parameters by using the calcium and contractility system (IonOptix).

Article Title: Bayesian Estimation of Muscle Mechanisms and Therapeutic Targets Using Variational Autoencoders.
Article Snippet: Cells were paced at 1 Hz and calcium transients were measured using the IonOptix Calcium and Contractility System.

Article Title: DNA-PKcs-Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia-Induced Cardiac Dysfunction in Type 1 Diabetes.
Article Snippet: [67] The Ionoptix Calcium and Contractility System was employed to quantify cardiomyocyte contractions, using a stimulation pattern of 0.5 Hz square pulses (20 ms, 10 V) under ambient conditions.

Article Title: NOX4-driven Mitochondrial Oxidative Stress in Aging Promotes Myocardial Remodeling and Increases Susceptibility to Ventricular Tachyarrhythmia.
Article Snippet: Aging-associated mitochondrial oxidative stress has been implicated in ventricular tachyarrhythmias (VT), but the specific proarrhythmic mechanisms of mitochondrial prooxidative systems remain unclear.. NADPH oxidase 4 (NOX4) expression in the heart increases with age, leading to mitochondrial oxidative stress, dysfunction, and adverse myocardial remodeling.. This study investigated the susceptibility to aging-associated ventricular arrhythmia and the associated triggers and substrates using transgenic mice with mitochondria-targeted Nox4 overexpression (Nox4TG mice).

Fluorescence:

Article Title: Stress-Induced Proteasome Sub-Cellular Translocation in Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias
Article Snippet: The recordings were conducted in the presence of Tyrode’s solution, and the temperature within the MEA chamber was kept at 37 ± 0.1 °C by means of temperature-maintaining system (GEFRAN 800, Montreal, QC, Canada). .. Intracellular Ca 2+ transients were recorded from small contracting CMs clusters by means of fura-2 fluorescence, using the IonOptix Calcium and Contractility system (IonOptix, Westwood, MA, USA) [ , , ]. ..

Isolation:

Article Title: Protein Kinase A Is a Master Regulator of Physiological and Pathological Cardiac Hypertrophy
Article Snippet: Single-point kinase profiling for PKAiGFP was performed by Thermo Fisher. .. Adult mouse ventricular myocytes and neonatal rat cardiomyocytes (NRCM) were isolated as reported.17 Adult mouse left ventricular (LV) myocyte (AMLVMs) contractions and calcium transients were measured with the Ionoptix Calcium and Contractility System as described previously.18 Myocyte protein/DNA ratio and cell surface area were measured. ..

Over Expression:

Article Title: Mst4, a novel cardiac STRIPAK complex–associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy
Article Snippet: .. A , contractility in adult rat ventricular myocytes (ARVCM) was assessed in the IonOptix calcium and contractility system after adenoviral Mst4 overexpression and compared to Lacz and also Mst4 overexpression and cotreatment with the kinase inhibitor hesperadin. ..

Article Title: Mst4, a novel cardiac STRIPAK complex associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
Article Snippet: .. Figure 4) MST4 overexpression results in enhanced cardiomyocyte contractility (A) Contractility in adult rat ventricular myocytes (ARVCM) was assessed in the IonOptix calcium and contractility system after adenoviral Mst4 overexpression and compared to Lacz and also Mst4 overexpression and co-treatment with the kinase inhibitor hesperadin. ..



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